Saffi or Saffie may refer to:
People Aurelio Saffi (1819–1890), Italian politician José Musalem Saffie (1924–2019), Chilean politician José Said Saffie (1930–2020) Peruvian-born Chilean businessman Saffie Lowe Ceesay, 21st century Gambian politician and civil servant Saffie Joseph Jr., a horse trainer whose horses were barred from the 2023 Kentucky Derby after two others died
Other uses Safi, Morocco, a city in Western Morocco Piazza Saffi, a plaza in Forlì, Italy Via Saffi, a major road in Casale Monferrato, Alessandria, Italy Saffie, a character in the Dutch comic strip Boes
See also Saffy (disambiguation), also includes Safy Safié, a 1909 opera