Samuel Chase (1741–1811) was a signer of the Declaration of Independence and justice of the United States Supreme Court.

Samuel Chase may also refer to:

Samuel Chase (New York politician) (1789–1838), U.S. congressman from New York USS Samuel Chase, Arthur Middleton class attack transport crewed by the United States Coast Guard during World War II SS Samuel Chase, a Liberty ship Samuel T. Chase (1868–1937), American tennis player

See also Samuel Chase House, West Newbury, Massachusetts