Class 22 may refer to:
Belgian Railways Class 22, a class of Bo-Bo electric locomotives in service 1959-2009 British Rail Class 22 1st use, a class of Bo-Bo diesel-hydraulic locomotives in service in the United Kingdom 1962-72 Dongbo 22-class barge British Rail Class 22 2nd use, a class of B-B electric locomotives in service in Belgium, France and the United Kingdom 1994-95 DR Class 22, a class of 2-8-2 steam locomotives in service in East Germany 1958-71 GER Class E22, 0-6-0T steam locomotives KTM Class 22, a class of Co-Co diesel electric locomotives in service in Malaya 1971-2010 NCC Class 22, a diesel mechanical locomotive in service in Northern Ireland 1944-65 NSB Class 22, a class of 2-8-0 steam locomotives in service in Norway 1906-58 PKP class ET22, a class of Co-Co electric locomotives in service in Poland since 1971 PKP class Ok22, a class of 4-6-0 steam locomotives in service in Poland 1923-39 South African Class 22E, a class of Co-Co electric locomotives in service in South Africa since 2015
See also Type 22 (disambiguation)