Santagata is a surname which was derived from Saint Agatha known as Agatha of Sicily. It has origins from Caserta and Naples. Notable people with the surname include:
Giulio Santagata (1949–2024), Italian politician Marco Santagata (1947−2020), Italian academic, writer, and literary critic Sandro Santagata, American physician and academic
Stage name Toni Santagata, stage name of Antonio Morese (1935–2021), Italian folk singer
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