Tverdokhlib () is a Ukrainian surname. Notable people with the surname include:
Marharyta Tverdokhlib (born 1991), Ukrainian long jumper Oleh Tverdokhlib (1969–1995), Ukrainian hurdler Sydir Tverdokhlib (1886–1922), Ukrainian poet, translator and politician Yehor Tverdokhlib (born 2000), Ukrainian footballer