Pierdomenico is a both surname and masculine given name of Italian origin, a combination of the names Pier, a form of Peter, and Domenico, which means 'lordly'. Notable people with the name include:
Surname Germano Pierdomenico (born 1967), Italian former professional racing cyclist
Given name Pierdomenico Baccalario (born 1974), Italian author Pierdomenico Perata (born 1962), Italian physiologist