Tirelli is a surname. Notable people with the surname include:
Alicia Tirelli (born 1985), American-born Puerto Rican retired footballer Davide Tirelli (born 1966), Italian middle-distance runner Mario Tirelli (born 1906, date of death unknown), Italian entomologist Mattia Tirelli (born 2002), Italian professional footballer Umberto Tirelli (1928–1992), Italian tailor
See also Palazzo Cassoli – Tirelli, building in Reggio Emilia Palazzo Tirelli, building in Reggio Emilia Tirelli Costumi, Rome-based costume house