FAM131A (Family with Sequence Similarity 131 Member A) is a protein that is encoded by the FAM131A gene in humans. Aliases for FAM131A include C3orf40, FLAT715, and PRO1378.
Gene The gene, FAM131A, which is found on the plus strand of chromosome 3 (3q27.1), spans 7,847 base pairs in humans. The FAM131A gene transcribes an mRNA sequence that is 2,437 nucleotides. FAM131A is most highly expressed in the brain, with a low tissue specificity.
Protein The FAM131A protein in humans is 366 amino acids in length, with a theoretical molecular weight of 39.5 kDa and a theoretical isoelectric point of 4.59. There have only been two isoforms found for the protein this gene encodes in humans, and isoform two is shorter at the N-terminus than isoform one due to amino acids 1-85 being absent in isoform two. It was also determined that Asparagine, Threonine, and Isoleucine are represented less in the FAM131A protein in comparison to most human proteins. However, Serine is more highly represented in the FAM131A protein in comparison to most human proteins. The FAM131A protein is predicted to be contained within the nucleus and in the nucleolus, and is predicted to be primarily localized to the nucleoli rim within the cell.
Post-translational modifications Five different post-translational modification sites have been predicted for the FAM131A protein. These include three different theoretical sumoylation sites and two different theoretical lysine acetylation sites.
Interacting proteins A few proteins have been found to be co-expressed alongside the FAM131 protein, including Von Willebrand Factor A Domain-Containing 5B2 (VWA5B2), Grid 2 Interacting Protein (GRID2IP), and Chordin (CHRD).
Homology
Orthologs were found for FAM131A in mammals (sequence identity ranging from 73.6%-92.3%), reptiles (sequence identity ranging from 48.5%-56.4%), birds (sequence identity ranging from 49.6%-54.0%), amphibians (sequence identity ranging from 47.1%-52.1%), and fish (sequence identity ranging from 26.2%-56.5%). The furthest date of divergence was found in fish, specifically Pretromyzon marinus, otherwise known as the Sea lamprey, at 599 million years ago. FAM131A was not found in any invertebrates, which could indicate that FAM131A is restricted to vertebrates.
Table of orthologs Species Name Common name Date of Divergence (mya) Accession number Sequence length (AA) Sequence identity to human proteinHomo sapiensHumans0NP_653236366100%Mus musculusHouse mouse87NP_59853936192.3%Phascolarctos cinereusKoala160XP_02086144036273.6%Sarcophilus harrisiiTasmanian devil160XP_03182396028364.1%Alligator mississippiensisAmerican alligator319XP_01933970832456.4%Gallus gallusChicken319XP_00364184133854.0%Haliaeetus leucocephalusBald eagle319XP_01057127927549.6%Aptenodytes forsteriEmporer penguin319XP_00928634927549.6%Python bivittatusBurmese python319XP_02502973630248.5%Rhinatrema bivittatumTwo-lined caecilian353XP_02947218529052.1%Xenopus tropicalisTropical clawed frog353XP_00491446034450.0%Rana temporariaCommon frog353XP_04020572134847.6%Bufo bufoCommon toad353XP_04028445726147.1%Protopterus annectensWest African lungfish408XP_043926343.136156.5%Danio rerioZebrafish431NP_00109362529343.4%Oryzias latipesJapanese rice fish431XP_00407930833834.4%Cheilinus undulatusHumphead wrasse431XP_04166011431831.4%Amblyraja radiataThorny skate464XP_03288807638051.8%Petromyzon marinusSea lamprey599XP_03280277838326.2%
Clinical significance Studies have found having high expression of FAM131A is prognostically unfavorable for patients with ovarian cancer or endometrial cancer.
References