Chester by-election may refer to several elections in Chester, England:

1869 Chester by-election, following the elevation to the peerage of Hugh Grosvenor 1916 Chester by-election, following the resignation of Robert Yerburgh 1940 City of Chester by-election, following the death of Sir Charles Cayzer 1956 City of Chester by-election, following the appointment of Basil Nield as Recorder of Manchester 2022 City of Chester by-election, following the resignation of Chris Matheson