Slither may refer to:
Slithering, a form of limbless terrestrial locomotion
Film and television Slither (1973 film), a comedy directed by Howard Zieff Slither (2006 film), a comedy horror film directed by James Gunn "Slither" (Sliders), an episode of Sliders "Slither" (Law & Order: Criminal Intent), an episode of Law & Order: Criminal Intent Slither (The Secret Circle), the 5th episode of the first season of the CW television series The Secret Circle
Comics and games Slither (comics), a fictional Marvel Comics mutant villain Slither, a 1982 arcade game, or its ColecoVision port Slither.io, a 2016 massively multiplayer browser game featuring snakes
Music Slither (album), a 2000 album by Earth Crisis "Slither" (song), a 2004 song by Velvet Revolver "Slither", a song by Metallica from ReLoad "Slither", a song by Opeth from Heritage
Other uses Cold Slither Slither, a character in the book The Letter for the King Slitherlink, a logic puzzle developed by publisher Nikoli