DePape is a surname with Dutch origins, mostly found in US, Canada, and Belgium.

People People with the name include:

Brigette DePape (born 1989), Canadian activist David Wayne DePape (born 1980), a suspect in the 2022 attack on Paul Pelosi Lorne De Pape (born 1955), Canadian-born New Zealander curler

Fictional characters Roy Depape, a fictional character from Stephen King's The Dark Tower series

See also De Paepe Pape (surname) Pape (disambiguation)