Gaetano or De Gaetano is an Italian surname. Notable people with the surname include:
Gaetano Gianluca Gaetano (born 2000), Italian professional footballer Juan Gaetano, Spanish pilot who may have been, in 1555, one of the first Europeans to find Hawaii Nick Gaetano, 21st century book illustrator Rino Gaetano (1950–1981), Italian singer-songwriter
De Gaetano Antonio De Gaetano (1934–2007), Italian race walker, father of Giuseppe Giuseppe De Gaetano (born 1966), Italian race walker Vincent A. De Gaetano (born 1952), Maltese judge
See also Paul DiGaetano (born 1953), American politician Gaetano, an Italian masculine given name Gaetano (disambiguation)