Buff is a nickname of:

E. U. Curtis Bohlen (born 1927), former president of the World Wildlife Fund and former United States Assistant Secretary of State for Oceans and International Environmental and Scientific Affairs Aldo Donelli (1907–1994), American football player and college and National Football League head coach, soccer player and college athletics administrator Buff Hardie, a member of the Scotland the What? comedy review act Geoff Hoon (born 1953), British politician Charles Kirkland (born 1950), American retired basketball player Buff Lord (1892–1985), English rugby league footballer Bob McCready (1940–2007), Canadian box lacrosse goaltender Buff Milner (1946–1996), New Zealand rugby union player Buff Wagner (1897–1962), American football player

See also BUFF (Big Ugly Fat Fucker/Fella), a nickname of the Boeing B-52 Stratofortress bomber aircraft