Masoumeh () is a feminine given name with Perso-Arabic origins. The name is a Persian spelling of the Arabic word Masuma, which translates to "innocent". English spelling variations include Ma'sumeh, Ma'soumeh, and Massumeh. Notable people with the name include:

Hazrat Masoumeh (790–816), also known as Fatimah bint Musa, daughter of the seventh Twelver Shia Imam, Musa al-Kazim

Given name Masoumeh Masoumeh Abad (born 1962), Iranian author, university professor, and conservative politician Masoumeh Aghapour Alishahi (born 1969), Iranian lecturer and politician Masoumeh Pashaei Bahram (born 1980), Iranian physician and politician Masoumeh Azizi Borujerdi (1920–1961), commonly known as Mahvash, Iranian singer, dancer, and actress Masoumeh Dadehbala (1942–1990), commonly known as Hayedeh, Iranian singer Masoumeh Ebtekar (born 1960), Iranian, former Vice President of Iran for Women and Family Affairs Massoumeh Massoumeh Seyhoun (1934–2010), Iranian painter and founder of Seyhoun Gallery Massumeh Massumeh Farhad (born 1955), American art historian and curator Masumeh Masumeh Makhija (born 1984), Canadian actress and model based in India

Other uses Shrine of Hadhrat Masoumeh, a Shia Islam shrine in Qom