Mbabazi is a surname. Notable people with the surname include:
Amama Mbabazi, (born 1949), Ugandan politician Esther Mbabazi (born 1949), Rwandan pilot Jacqueline Mbabazi (born 1954), Ugandan educator, politician and businesswoman Janet Mbabazi (born 1996), Ugandan cricketer Lillian Mbabazi (born 1984), Rwandan-Ugandan recording artist and entertainer Pamela Mbabazi (born 1969), Ugandan university professor, academic, and academic administrator Philbert Aimé Mbabazi (born 1990), Rwandan filmmaker Rosemary Mbabazi, Rwandan businesswoman and politician