William D. Clarke, Sr. (born 1941) is an American diplomat. Clarke served as the United States Ambassador to Eritrea from 1998 to 2001. He previously served over 30 years as a diplomat and member of the Diplomatic Security Service, including becoming the Deputy Assistant Secretary for Countermeasures and Information Security before his ambassadorship.
On October 3, 2022, the State Department announced a fellowship enabling a pipeline to become Diplomatic Security Service Special Agent named in Clarke's honor.
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