Al-Khelaifi or Al-Khulaifi (: "my successor"); is an Arabic language surname which in both of its Latin transcriptions (Khelaifi and Khulaifi) of the Perso-Arabic alphabet is also common among the Arab diaspora. Notable people with the surname include:
Al-Khulaifi Mohamed Bin Mubarak Al-Khulaifi (born 1999), Qatari swimmer Noah Al-Khulaifi (born 1946), Qatari diplomat Sultan Khlaifa al-Khulaifi, Qatari blogger, human rights activist Yacob Al-Khulaifi (born 2001), Qatari swimmer
Al-Khelaifi Aisha Al-Khelaifi, Qatari chess player Fatima Al-Khelaifi, Qatari researcher Kholoud Al-Khelaifi, Qatari chess player Nasser Al-Khelaifi (born 1973), Qatari businessman and sports executive Salama Al-Khelaifi, Qatari chess player