CCDC184

Coiled-coil domain-containing 184 (CCDC184) is a protein which, in humans, is encoded by the CCDC184 gene.

Gene

Alias for the CCDC184 gene is C12orf68, chromosome 12 open reading frame 68. CCDC184 mRNA sequence, which is 2283 nucleotides in length, and is composed of 1 exon.

Expression

Human CCDC184 is primarily expressed in the components of the brain, such as hypothalamus, pons, pituitary gland. The gene's expression is enhanced and/or over-expressed in the brain tissue expression. Tissue expression cluster predicted Pituitary gland - Hormone signaling

Protein

Overview CCDC184 Protein is 194 amino acid and contains a domain of unknown function, DUF4677, which spans for 193 amino acid long . CCDC184 protein has a theoretical molecular weight of 20,484 dalton and an isoelectric point of 4.04. This indicates the acidic nature of the sequence. The molecular function of the protein is protein binding

Post translational Modification

CCDC184 contains various predicted post-translational modification domains, including phosphorylation, SUMOylation, Glutaredoxin, Myristoylation, Glutamic acid-rich region, and acetylation. The sites include S23, T24, and Y36. + Predicted Post Modification sites/domains of CCDC184 human protein. Modification Amino acid Region Phosphorylation 76, 113, 155, 120, 122, 162 Myristoylation 103-108, 109-114, 124-129, 166-172 Glutaredoxin domain 1-62 Glutamic acid-rich region 136-146 SUMOylation 102-106, 183-187

P = Phosphorylation site, Sumo: Sumo interacting regions, DUF4677: domain of unknown function

Structure The human CCDC184 protein is predicted to be localized in the cytoplasm

AlphaFold figure indicates 3D model of CCDC184. The colors indicate the charged regions of the structure

Conceptual translation

The annotated elements shown in the conceptual translation for human CCDC184 protein is post-translational modifications, alpha helices, SUMOylation, Lysine acetylation, domain of unknown function.

Homology

CCDC184 is found only in mammals. 183 organisms that have orthologs with the human gene CCDC184.

Table of Orthologs

Orthologs for CCDC184 are only found in mammals. The most distantly related species to human CCDC184 with a date of divergence of 160 MYA is the opossum. The Tasmanian devil also has a date of divergence of 160 MYA. The table indicates a various selection portion of the mammals' list.

+ Table of Orthologs Taxonomic Order Genus and Species Common name Accession number Sequence length(aa) Date of Divergence(MYA) % Identity to the human protein % Similarity to the human protein Primate Homo sapiens Human NP_001013657.3 194 0 100 100Primate Carlito syrichta Philippine tarsier XP_008067440.1 194 69 93.3 97.4 Scandentina Tupaia chinensis Chinese tree shrew XP_006163517.1 85 85 89.7 93.8 Rodentia Mus musculus Mouse NP_808384.2 191 87 90.2 82.8 Carnivora Lontra canadensis River otter XP_032732811.1 193 94 93.8 96.9 Carnivora Ursus americanus American black bear XP_045656783.1 195 94 94.9 96.9 Cetacea Neophocaena asiaeorientalis asiaeorientalis Finless porpoise XP_024592814.1 195 94 92.8 95.9 Cetacea Delphinapterus leucas Beluga whale XP_022428046.1 195 94 93.3 96.4Artiodactyla Camelus ferus Bactrian camel XP_006196007.2 195 94 94.9 97.4 Artiodactyla Sus scrofa Wild boar XP_020948280.1 195 94 92.8 95.4 Chiroptera Desmodus rotundus Vampire bat XP_024431436.1 195 94 90.3 93.8 Pilosa Choloepus didactylus Two-toed sloth XP_037701005.1 196 99 88.8 92.9 Proboscidea Elephas maximus indicus Indian elephant XP_049738921.1 197 99 89.3 94.9 Cingulata Dasypus novemcinctus Nine-banded armadillo XP_004470453.1 192 99 90.2 93.3 Marsupial Gracilinanus agilis Agile gracile opossum XP_044534020.1 186 160 72.8 80 Marsupial Sarcophilus harrisii Tasmanian devil XP_031793886.1 187 160 69.2 77.6

The figure indicates a chart showing the divergence of CCDC184, Cytochrome C and Fibrogen Alpha.

Interaction and clinical significance Predicted interactions for the CCDC184 gene were seen and the interactions revolved around enabling protein binding activity. Expressions of CCDC184 were connected to studies done on tissue samples for breast cancer somatic mutations

References