Calmodulin-regulated spectrin-associated protein 3

Calmodulin-regulated spectrin-associated protein family member 3 (CAMSAP3) is a human protein encoded by the gene CAMSAP3. The protein is commonly referred to as Nezha.

Function CAMSAP3 acts as a minus-end anchor of microtubules, and binds to them through its CKK domain.

In epithelial cells, it anchors microtubules to the apical cortex, causing them to grow in an apical-to-basal direction. This gives the epithelial cells their rectangular shape.

In other species In early mouse embryogenesis, the interphase bridge linking sister cells is enriched with CAMSAP3.

See also

CAMSAP1 CAMSAP2

References