Chikhladze () is a Georgian surname. Notable people with the surname include:
Anzor Chikhladze (born 1949), Russian professional football coach and a former player Lado Chikhladze (born 1985), Georgian former professional tennis player Sandro Chikhladze (born 1965), Soviet equestrian Shalva Chikhladze (1912–1997), Soviet light-heavyweight wrestler from Georgia