Brandon Nakashima defeated Marcos Giron in the final, 6–4, 6–4 to win the singles tennis title at the 2022 San Diego Open. It was his first ATP Tour title, and he won it in his hometown of San Diego.
Casper Ruud was the reigning champion, but competed at the Laver Cup instead.
Seeds The top four seeds received a bye into the second round.
Draw
Finals
Top half
Bottom half
Qualifying Seeds
Qualifiers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
References
External links Main draw Qualifying draw