TEKTIP1, also known as tektin-bundle interacting protein 1, is a protein that in humans is encoded by the TEKTIP1 gene.
Gene Tektin bundle interacting protein 1 (TEKTIP1) is a protein which in humans is encoded by the TEKTIP1 mRNA. The longest mRNA produced is 826 bases long.
Aliases Alias of the protein is C19orf71.
Locus
The TEKTIP1 gene is located at 19p13.3.
Transcriptional Regulation
Several predicted transcription factors may bind in the promoter region: TFDP1, PLAGL1, ZSCAN4, POU2F3.
Chemical Interactions
Acrylamide, cisplatin, and silicon dioxide decrease expression, while butanal (butyraldehyde), and pentanal increase expression of TEKTIP1 mRNA.
Sequence orthology also suggests that valproic acid increases methylation of TEKTIP1 mRNA.
Protein The mRNA of TEKTIP1 is 654 nucleotides long. It contains five exons. The human TEKTIP1 protein is 209 amino acids long and has a predicted molecular mass of 24.5 kDa. The human protein has a theoretical isoelectric point of 9.1.
Isoforms
There are two splice isoforms of the protein, X1 and X2. +X1 & X2 Isoform OrthologsX1 X2Tibetan macaqueChimpanzeeOlive baboonOlive baboonPanamanian white-faced capuchinCommon marmosetGolden and Black snub-nosed monkeysGolden sub-nosed monkeyElkElkRed deerRed deerGreater horseshoe batBatsRed foxPolar bear
Characteristics & structure
TEKTIP1 is highly enriched in tryptophan and tyrosine. Additionally, the protein is semi-enriched in arginine and proline.
Expression TEKTIP1 is tissue specific and is found in higher levels in the kidney, testis and thymus.
In fetal development, it is found in higher levels in the Adrenal glands during weeks 16–20.
TEKTIP1 protein is said to be specific to the testis and is found in early spermatids during spermatogenesis.
Evolution
Orthologs
Over 240 organisms have orthologs with human gene TEKTIP1. The most distant organism with an orthologous sequence to human TEKTIP1 is the West African lungfish (estimated date of divergence of 408 MYA). +Selected Orthologs for TEKTIP1Genus and speciesCommon nameTaxonomic groupMedian Date of Divergence (MYA)Accession #Sequence length (aa)Sequence identity to human protein %Sequence similarity to Human Protein %Homo sapiensHumanPrimates/Hominidae0NP_001129052.1209100100Pan troglodyteChimpanzeePrimates6.4XP_003316050.120998.198.6Mus musculusMouseRodentia87NP_001014836.221745.660.4Bos taurusCowArtiodactyla94NP_00107055020876.684.2Panthera tigrisTigerCarnivora94XP_042833719.121034.138.9Orcinus orcaKiller whaleCetacea94XP_012394771.22166373.1Phascolarctos cinereusKoalaDiprodontia160XP_020824948.121152.967.4Haliaeetus leucocephalusBald EagleAccipitiformes319XP_010580112.120641.452Dromaius novaehollandiaeEmuAves319XP_025961204.119044.856.7Gallus gallus domesticusChickenAves319XP_015155269.218838.248.4Crocodylus porosusSaltwater CrocodileCrocodilia319XP_019406144.121054.368.3Caretta carettaLoggerhead Sea TurtleTestudines319XP_048687032.121647.857.3Zootoca viviparaCommon lizardSquamata319XP_034975173.120048.859.5Crotalus tigrisTiger RattlesnakeSquamata319XP_039190693.119945.857.5Protobothrops mucrosquamatusVenomous Pit ViperSquamata319XP_015665555.119945.156.7Bufo bufoCommon ToadSalientia353XP_04027637513624.734.3Geotrypetes seraphiniGaboon CaecilianCaecilians353XP_033813379.115636.145.8Microcaecilia unicolorTiny CaecilianCaecilians353XP_030074922.114234.342.6Protopterus annectensWest African LungfishActinopterygii 408XP_043910031.114228.639
References
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