The 2021 Cannons Lacrosse Club season was the Cannons Lacrosse Club's 21st season and their first Premier Lacrosse League season.

Schedule + 2021 schedule Date Opponent Result June 4 Redwoods Lacrosse Club L 12-13 June 6 Waterdogs W 13-7 June 12 Whipsnakes L 15-14 June 27 Atlas L 17-18 July 3 Chaos L 10-14 July 9 Waterdogs L 19-7 July 11 Archers W 13-12 August 1 Atlas L 12-13 August 14 Chrome W 13-10 August 20 Archers L10-13

Expansion It was announced that the Cannons would join the PLL as part of the MLL–PLL merger on December 16, 2020. They held their expansion draft on March 13, 2021.

Rebrand The Cannons moved from Veterans Memorial Stadium (Quincy, Massachusetts) to Medford when hosting their preseason training. They also rebranded from the "Boston Cannons" to Cannons Lacrosse Club.

Regular season The Cannons played their first PLL game in Gillette Stadium on June 4, 2021 in a 12-13 loss to Redwoods Lacrosse Club. They finished the season 3-6, earning a playoff spot.

Playoffs The Cannons were eliminated from the playoffs in a quarterfinals 13-9 loss to Atlas Lacrosse Club.

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