The 2022 Città di Como Challenger was a professional tennis tournament played on clay courts. It was the sixteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Como, Italy between 29 August and 4 September 2022.

Singles main-draw entrants Seeds Country Player Rank1 SeedMarco Cecchinato1411Giulio Zeppieri1462Francesco Passaro1483Nikola Milojević1814Matteo Arnaldi1885Riccardo Bonadio1896Stefano Travaglia1907Andrea Arnaboldi1978 1 Rankings are as of 22 August 2022.

Other entrants The following players received wildcards into the singles main draw: Federico Arnaboldi Gianmarco Ferrari Matteo Gigante

The following player received entry into the singles main draw as a special exempt: Lucas Gerch

The following players received entry into the singles main draw as alternates: Oleksii Krutykh Lucas Miedler

The following players received entry from the qualifying draw: Adrian Andreev Marius Copil Cezar Crețu Nicolas Moreno de Alboran Mariano Navone Giovanni Oradini

The following player received entry as a lucky loser: Kenny de Schepper

Champions Singles

Cedrik-Marcel Stebe def. Francesco Passaro 7–6(7–2), 6–4.

Doubles

Alexander Erler / Lucas Miedler def. Dustin Brown / Julian Lenz 6–1, 7–6(7–3).

References