Hypostomus regani is a species of catfish in the family Loricariidae. It is native to South America, where it occurs in the basins of the Paraná River, the Paraguay River, and the Uruguay River.Burgess, W.E., 1989. An atlas of freshwater and marine catfishes. A preliminary survey of the Siluriformes. T.F.H. Publications, Inc., Neptune City, New Jersey (USA). 784 p. The species reaches SL and is believed to be a facultative air-breather.

Etymology The fish is named in honor of English ichthyologist Charles Tate Regan (1878–1943), of the Natural History Museum in London.

Aquarium H. regani appears in the aquarium trade, where it is typically known as the giant white-spot pleco.

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