Alex de Minaur defeated Jenson Brooksby in the final, 6–3, 6–3 to win the singles title at the 2022 Atlanta Open. It was de Minaur's second Atlanta title, the first being in 2019.
John Isner was the defending champion, but lost in the quarterfinals to Brooksby.
Seeds The top four seeds received a bye into the second round.
Draw
Finals
Top half
Bottom half
Qualifying Seeds
Qualifiers
Lucky losers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
References
External links Main draw Qualifying draw