Marie Bouzková defeated Anastasia Potapova in the final, 6–0, 6–3 to win the singles tennis title at the 2022 Prague Open. It was her maiden WTA Tour title.
Barbora Krejčíková was the defending champion, but lost in the second round to Nao Hibino.
Seeds
Draw
Finals
Top half
Bottom half
Qualifying Seeds
Qualifiers
Lucky losers
Qualifying draw First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
References
External links Main draw Qualifying draw