Noxolo is a Southern African feminine given name. It is also a surname.

People with the given name Noxolo Cesane (born 2000), South African soccer player Noxolo Kiviet, South African politician Noxolo Maqashalala (1977 – 2021), South African actress Noxolo Mathula (born 1993), South African actress, model, and musician Noxolo Nogwaza (1987 – 2011), South African LGBT rights activist

People with the surname Patricia Noxolo, British geographer