The 1980–81 season was the 20th season of Pumas UNAM in the top flight of Mexican football. In addition to the domestic league, the club participated in this season's editions of the CONCACAF Champions' Cup, and the Copa Interamericana.
Competitions Overview
CONCACAF Champions' Cup
Pumas UNAM entered the tournament in the third round, after their opponent withdrew from the competition in the first round.
Third round
Final round
Copa Interamericana
Final
External links