De Agostini is a surname of Italian origin. Notable people with the surname include:
Alberto Maria de Agostini (1883–1960), Italian missionary, explorer and geographer Giovanni Maria de Agostini (1801–1869), lay monk of Italian origin Luigi De Agostini (born 1961), Italian footballer Doris de Agostini (1958–2020), Swiss skier
See also De Agostini (disambiguation) Agostini