Blayton is a surname. Notable people with the surname include:
Betty Blayton (1937–2016), American activist, advocate, artist, arts administrator, educator, lecturer J. Blaine Blayton (1905–2002), African-American physician in the Williamsburg, Virginia, area Jesse B. Blayton (1897–1977), radio entrepreneur, civil rights activist, professor, accountant, businessman
See also J. Blaine Blayton Elementary School, southeastern Virginia Blaton Blaydon Blyton