Manuel Núñez may refer to:
Manuel Núñez Asencio (born 1957), Dominican historian Manuel Ángel Núñez Soto (born 1951), Mexican politician Manuel Núñez Pérez (born 1933), Spanish politician Manuel Núñez Tovar (1872–1928), Venezuelan naturalist
See also Chema (footballer, born 1997), José Manuel Núñez Martín, Spanish footballer Cristian Núñez (footballer, born 1980), Cristian Manuel Núñez, Argentine footballer Dom Núñez (born 1995), Dominic Manuel Núñez, American baseball player Manuela Nuñez de Almeida, 18th-century British Jewish poet Xosé Manoel Núñez Seixas (born 1966), Spanish historian