Osypenko or Osipenko () is a Ukrainian surname derived from the given name Osyp, equivalent to English Joseph. Its Belarusian equivalent is Asipenka or Asipienka ().

Notable people with the surname include: Alexander Osipenko (disambiguation), multiple individuals Alla Osipenko (born 1932), Russian ballerina Dzmitry Asipenka (born 1982), Belarusian footballer Inna Osypenko-Radomska (born 1982), Ukrainian-Azerbaijani sprint kayaker Petro Osypenko (1921–unknown), Soviet-Ukrainian public prosecutor Polina Osipenko (1907–1939), Soviet-Ukrainian pilot

See also