The Eastern Missouri Conference is a high school athletic conference comprising small-size high schools located in eastern central Missouri. The conference members are located in Audrain, Callaway, Lincoln, Montgomery, Pike, Ralls and Warren counties.

Members School name Mascot Colors City County School type Bowling Green Bobcats Bowling Green Pike Public Clopton Hawks Clarksville Pike Public Elsberry Indians Elsberry Lincoln Public Louisiana Bulldogs Louisiana Pike Public Mark Twain Tigers Center Ralls Public Montgomery County Wildcats Montgomery City Montgomery Public North Callaway Thunderbirds Kingdom City Callaway Public Silex Owls Silex Lincoln Public Van-Far Indians Vandalia Audrain Public Wellsville-Middletown Tigers Wellsville Montgomery Public Wright City Wildcats Wright City Warren Public

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