S101 may refer to:
Asus Eee PC S101, a netbook computer from Asus Dome S101, a sports car prototype for endurance racing Highway S101, proposed northern extension of New Jersey Route 101, never built , the United Kingdom's first nuclear-powered submarine New Jersey State Highway S101, a controlled-access toll road running north–south in eastern New Jersey , a Heroine-class submarine in service with the South African Navy Soviet submarine S-101, Stalinets-class submarine of the Soviet Navy