The men's singles of the 2022 I.ČLTK Prague Open tournament took place on clay in Prague, Czech Republic.
Tallon Griekspoor was the defending champion but chose not to compete.
Pedro Cachin won the title after defeating Lorenzo Giustino 6–3, 7–6(7–4) in the final.
Seeds
Draw
Finals
Top half
Bottom half
References
External links Main draw Qualifying draw