Guill is a surname. Notable people with the surname include:
Antonio de Guill y Gonzaga (died 1768), Spanish colonial administrator Ben H. Guill (1909–1994), member of the U.S. House of Representatives from Texas Julianna Guill (born 1987), American actress Marshall Guill (1897–1931), American football and baseball player
See also Guill., taxonomic author abbreviation of Jean Baptiste Antoine Guillemin (1796–1842), French botanist