John Hopper may refer to:
John Hopper (politician) (John D. Hopper) (1923–1996), member of the Pennsylvania State Senate John Hopper (epidemiologist) (1950–2024), Australian genetic epidemiologist and professor John D. Hopper Jr. (born 1946), United States Air Force general
See also John Hopper House, in Hackensack, Bergen County, New Jersey, United States John Hopper Mathews (1926–2015), American and Osage Nation actor, professor, and research scientist John Hoppner (1758–1810), English portrait painter