The 2022 Open Città della Disfida was a professional tennis tournament played on clay courts. It was the 22nd edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Barletta, Italy between 11 and 17 April 2022.

Singles main-draw entrants

Seeds Country Player Rank1 SeedGilles Simon1361Nuno Borges1432Zdeněk Kolář1503Jurij Rodionov1624Franco Agamenone1675Enzo Couacaud1796Constant Lestienne1887Kacper Żuk1898 1 Rankings are as of 4 April 2022.

Other entrants The following players received wildcards into the singles main draw: Luca Nardi Oleksandr Ovcharenko Francesco Passaro

The following players received entry into the singles main draw as alternates: Evgeny Karlovskiy Jelle Sels Alexander Shevchenko

The following players received entry from the qualifying draw: Matteo Arnaldi Luciano Darderi Titouan Droguet Francesco Forti Lucas Gerch Miljan Zekić

Champions

Singles

Nuno Borges def. Miljan Zekić 6–3, 7–5.

Doubles

Evgeny Karlovskiy / Evgenii Tiurnev def. Ben McLachlan / Szymon Walków 6–3, 6–4.

References