The 2022 Costa Cálida Región de Murcia was a professional tennis tournament played on clay courts. It was the 3rd edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Murcia, Spain, between 4 and 10 April 2022.

Singles main-draw entrants Seeds Country Player Rank1 SeedNorbert Gombos1121Juan Manuel Cerúndolo1222Dennis Novak1403Tseng Chun-hsin1484Mario Vilella Martínez1725Maximilian Marterer1926Marco Trungelliti1947Andrea Pellegrino1968 1 Rankings are as of 21 March 2022.

Other entrants The following players received wildcards into the singles main draw: Ivan Gakhov Carlos Gimeno Valero Carlos Sánchez Jover

The following players received entry from the qualifying draw: Ulises Blanch Miguel Damas Michael Geerts Oleksii Krutykh Daniel Mérida Rudolf Molleker

The following player received entry as a lucky loser: Christopher Heyman

Champions Singles

Tseng Chun-hsin def. Norbert Gombos 6–4, 6–1.

Doubles

Íñigo Cervantes / Oriol Roca Batalla def. Pedro Cachin / Martín Cuevas 6–7(4–7), 7–6(7–4), [10–7].

References