HMS Salisbury was a 50-gun fourth-rate ship of the line of the Royal Navy.

Service The Salisbury was built at Chatham Dockyard by Joseph Harris to the design of Sir Thomas Slade, and launched on 2 October 1769. She participated in Admiral Edward Hawke's Western Squadron in the Mediterranean, and undertook several voyages to the West Indies.

Fate The Salisbury was grounded on 13 May 1796 near Santo Domingo and surrendered to the Spanish.

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