Sir John is primarily a nickname for Ghanaian lawyer and politician Kwadwo Owusu Afriyie.

Sir John may also refer to:

Sir John (horse), a 19th-century racehorse Sir John (magazine), a Canadian online magazine "Sir John", a song by Don Patterson on the album Opus De Don Sir John (make-up artist), an American make-up artist Sir John, a fictional villain played by Raza Murad in the 1989 Indian film Ram Lakhan

See also