Novo is a Portuguese and Galician surname. Notable people with the surname include:
Álvaro Novo (born 1978), Spanish footballer Emanuel Novo (born 1992), Portuguese footballer Ferruccio Novo (1897–1974), Italian footballer Honório Novo (born 1950), Portuguese politician Ignacio Novo Sampol, Cuban exile and militant Luís Novo (born 1970), Portuguese long-distance runner Nacho Novo (born 1979), Spanish footballer Nancho Novo (born 1958), Spanish actor Pelayo Novo (born 1990), Spanish footballer Salvador Novo (1904–1974), Mexican writer and poet