Orphanides is a surname. Notable people with the surname include:
Andreas G. Orphanides (born 1955), Cypriot professor and university administrator Athanasios Orphanides (born 1962), Cypriot economist Panicos Orphanides (born 1961), Cypriot football manager Theodoros G. Orphanides (1817–1886), Greek botanist
See also Georgios Orphanidis (1859–1942), Greek sports shooter Orfanidis, surname