Museum of the Great Plains or Great Plains Museum may refer to:

Museum of the Great Plains (Oklahoma), in Lawton, Oklahoma Museum of the Great Plains (Wichita County, Kansas), in Leoti, Kansas, in the National Register-listed Municipal Auditorium and City Hall Great Plains Black History Museum, North Omaha, Nebraska Great Plains Art Museum, at the Center for Great Plains Studies at the University of Nebraska–Lincoln Great Plains Transportation Museum, Wichita, Kansas Great Plains Dinosaur Museum and Field Station, Malta, Montana former Delbridge Museum of Natural History, Sioux Falls, South Dakota

See also Plains Art Museum, Fargo, North Dakota Southern Plains Indian Museum, Anadarko, Oklahoma Laramie Plains Museum, Laramie, Wyoming Great Plains section of the Hungarian Open Air Museum, Szentendre, Hungary