Clayden is a surname. Notable people with the surname include:
Arthur Clayden (1829–1899), New Zealand journalist and emigration agent Arthur W. Clayden (1855-1944), British scientist, first principal of Royal Albert Memorial College Bertha Clayden (1881−1958), British police officer Charles Clayden, English footballer George Clayden (1903–1990), Australian footballer James Clayden, Australian director and painter John Clayden (1904–1986), South African judge Jonathan Clayden (born 1968), British chemist JS Clayden (born 1971), British singer-songwriter Pauline Clayden (1922–2026), British ballerina Peter Clayden (1827–1902), British journalist and author Rodney Clayden (born 1945), British swimmer