Gilkison is a surname. Notable people with the surname include:
Alan Gilkison (1909–1990), New Zealand company director Andrea Gilkison (fl. 1970s–1980s), New Zealand guitarist in the Wide Mouthed Frogs, predecessor of The Crocodiles Andrew Gilkison (fl. 1770s–1780s), innkeeper and namesake of Gilkison's Corner, Pennsylvania Frank Gilkison (1877–1955), Justice of the Indiana Supreme Court Jason Gilkison (born c. 1985), Australian professional ballroom dance champion and choreographer Jasper Tough Gilkison (fl. 1850s–1890s), Indian Department superintendent involved in the founding of Ohsweken, Ontario John Gilkison (1874–1964), New Zealand businessman in the 1957 New Year Honours (New Zealand) William Gilkison (1777–1833), Scottish-born British soldier who founded Elora, Ontario