Duff is a nickname of:
Duff Armstrong (1833–1899), American soldier successfully defended by Abraham Lincoln against the charge of murder Duff Goldman (born 1974), star of Food Network's reality show Ace of Cakes Duff Holbrook (1923–2015), American wildlife biologist, forester and outdoorsman John Lowe (musician) (1942–2024), English pianist for The Quarrymen, a forerunner of The Beatles Duff McKagan (born 1964), bassist of Guns N' Roses and former bassist of Velvet Revolver Duff Pattullo (1873–1956), Canadian politician, 22nd premier of British Columbia Dufferin Roblin (1917–2010), Canadian businessman and politician