Ampatuan is a surname and it refers to a political family in the Philippines. Notable people with the surname include:
Andal Ampatuan Sr., former governor of Maguindanao province, the Philippines, and co-suspect in the Maguindanao massacre Andal Ampatuan Jr., former mayor of Datu Unsay, Maguindanao province, and primary suspect in the Maguindanao Massacre Zaldy Ampatuan (b. 1967), former governor of the Autonomous Region in Muslim Mindanao (ARMM) in the Philippines
See also Ampatuan, Maguindanao del Sur, municipality in the Philippines