The 2021 McDonald's All-American Girls Game was an all-star basketball game that was scheduled be held in 2021. The game's rosters featured the best and most highly recruited high school girls graduating in the class of 2021. The game would have been the 20th annual version of the McDonald's All-American Game first played in 2002. Due to the impact of the COVID-19 pandemic, the game was cancelled and the players were honored virtually. The 24 players were selected from over 700 nominees by a committee of basketball experts. They were chosen not only for their on-court skills, but for their performances off the court as well.

Rosters The roster was announced on February 23, 2021. South Carolina had the most selections with four, while North Carolina, Texas and UConn had three selections each.

ESPNW100 RankNameHeight PositionHometownHigh schoolCollege choice20 Destiny Adams 6–3 W Whiting, New Jersey Manchester Township High School North Carolina21 Clarice Akunwafo 6–5 P Inglewood, California Rolling Hills Preparatory USC16 Sonia Citron 6–1 G Scarsdale, New York Ursuline High School Notre Dame13 Maryam Dauda 6–4 P Bentonville, Arkansas Bentonville High School Baylor15 Amari DeBerry 6–5 F Williamsville, New York Williamsville South High School UConn11 Brooke Demetre 6–2 W Foothill Ranch, California Mater Dei High School Stanford5 Caroline Ducharme 5–10 G Milton, Massachusetts Noble and Greenough School UConn4 Sania Feagin 6–3 F Ellenwood, Georgia Forest Park High School South Carolina1 Azzi Fudd 5–11 G Washington, D.C. St. John's College High School UConn14 Bree Hall 5–11 G Dayton, Ohio Wayne High School South Carolina10 Rori Harmon 5–6 PG Houston, Texas Cypress Creek High School Texas37 Jillian Hollingshead 6–4 F Marietta, Georgia McEachern High School Georgia24 Kyndall Hunter 5–8 PG Houston, Texas Cypress Creek High School Texas19 Kiki Iriafen 6–2 F North Hills, California Harvard-Westlake School Stanford2 Raven Johnson 5–8 PG Atlanta, Georgia Westlake High School South Carolina32 Greta Kampschroeder 6–0 G Naperville, Illinois Naperville North High School Oregon State9 Teonni Key 6–3 W Cary, North Carolina Cary High School North Carolina27 Rayah Marshall 6–3 G Los Angeles, California Lynwood High School USC17 Kayla McPherson 5–7 PG Hull, Georgia Madison County High School North Carolina6 Aaliyah Moore 6–1 F Moore, Oklahoma Moore High School Texas34 Reigan Richardson 5–11 G Huntersville, North Carolina Cannon School Georgia3 Saniya Rivers 6–0 G Wilmington, North Carolina Eugene Ashley High School South Carolina12 Payton Verhulst 6–1 G De Soto, Kansas Bishop Miege High School Louisville7 Jersey Wolfenbarger 6–5 W Fort Smith, Arkansas Northside High School Arkansas

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